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"Clinical Research"

First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway

The powerful gene-editing technique called CRISPR has been in the news a lot. And not all the news has been good: A Chinese scientist stunned the world last year when he announced he had used CRISPR to create genetically modified babies. But scientists have long hoped CRISPR — a technology that allows scientists to make... Read More »

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The powerful gene-editing technique called CRISPR has been in the news a lot. And not all the news has been good: A Chinese scientist stunned the world last year when he announced he had used CRISPR to create genetically modified babies. But scientists have long hoped CRISPR — a technology that allows scientists to make… Read More »

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Guardant’s blood test might replace biopsies for some lung cancer patients, study says

Could a blood test help more lung cancer patients get drugs that are targeted to the genetic weaknesses of their tumors? Yes, according to summary results of a 282-patient clinical trial being made available Wednesday. The result is a boon for Guardant Health, the San Francisco-based startup that sells the test, Guardant360, which is a... Read More »

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Could a blood test help more lung cancer patients get drugs that are targeted to the genetic weaknesses of their tumors? Yes, according to summary results of a 282-patient clinical trial being made available Wednesday. The result is a boon for Guardant Health, the San Francisco-based startup that sells the test, Guardant360, which is a… Read More »

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Immunotherapies could change kidney cancer care, studies suggest

The way doctors typically approach kidney cancer treatment could be evolving. Two separate studies published Saturday in the New England Journal of Medicine showed that renal cell cancer patients had significantly better outcomes when their treatment combined the targeted therapy drug axitinib, or Inlyta, with an immunotherapy — one study used pembrolizumab, or Keytruda, and... Read More »

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The way doctors typically approach kidney cancer treatment could be evolving. Two separate studies published Saturday in the New England Journal of Medicine showed that renal cell cancer patients had significantly better outcomes when their treatment combined the targeted therapy drug axitinib, or Inlyta, with an immunotherapy — one study used pembrolizumab, or Keytruda, and… Read More »

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Compounded Pain Creams Ineffective for Chronic Pain

Compounded topical pain creams work no better than placebo creams and should not be used to treat chronic pain, according to a new study published in the Annals of Internal Medicine. Researchers at the Walter Reed National Military Medical Center enrolled nearly 400 people with chronic neuropathic, joint or muscle pain in the study. Some... Read More »

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Compounded topical pain creams work no better than placebo creams and should not be used to treat chronic pain, according to a new study published in the Annals of Internal Medicine. Researchers at the Walter Reed National Military Medical Center enrolled nearly 400 people with chronic neuropathic, joint or muscle pain in the study. Some… Read More »

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“Christmas Berry” Plant Compound Could Fight Uveal Melanoma

A molecule derived from a type of primrose could prove to be a potent inhibitor of metastatic growth for a rare and aggressive cancer. Christmas berry plant (Ardisia crenata) PHILADELPHIA — Doctors diagnose about 2,000 adults with uveal melanoma, a cancer of the eye, every year. In half of cases, the disease metastasizes to the... Read More »

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A molecule derived from a type of primrose could prove to be a potent inhibitor of metastatic growth for a rare and aggressive cancer. Christmas berry plant (Ardisia crenata) PHILADELPHIA — Doctors diagnose about 2,000 adults with uveal melanoma, a cancer of the eye, every year. In half of cases, the disease metastasizes to the… Read More »

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Chemo ‘Cocktail’ Embraced as Pancreatic Cancer Breakthrough

When researchers announced that a four-drug chemotherapy regimen can add years to the lives of some patients with earlier-stage pancreatic cancer, doctors didn’t wait. Trial results were released last spring, and were immediately “practice-changing,” said Dr. Hedy Kindler, an oncologist at the University of Chicago who was not involved in the trial. Dr. James Biagi,... Read More »

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When researchers announced that a four-drug chemotherapy regimen can add years to the lives of some patients with earlier-stage pancreatic cancer, doctors didn’t wait. Trial results were released last spring, and were immediately “practice-changing,” said Dr. Hedy Kindler, an oncologist at the University of Chicago who was not involved in the trial. Dr. James Biagi,… Read More »

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Australian researchers develop 10-minute cancer test

Researchers in Australia have developed a 10-minute test that can detect the presence of cancer cells anywhere in the human body, according to a newly published study. The test was developed after researchers from the University of Queensland found that cancer forms a unique DNA structure when placed in water. The test works by identifying... Read More »

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Researchers in Australia have developed a 10-minute test that can detect the presence of cancer cells anywhere in the human body, according to a newly published study. The test was developed after researchers from the University of Queensland found that cancer forms a unique DNA structure when placed in water. The test works by identifying… Read More »

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E-Alerts Dramatically Cut Heart Attack Rate for People Hospitalized With A-Fib

A simple pop-up alert on a computer screen could help save the brains and hearts of many hospital-bound people with an irregular heartbeat, a new clinical trial reveals. Rates for heart attack and stroke plunged by close to 90 percent in people helped by the new program, the study found. The computer alert warns doctors... Read More »

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A simple pop-up alert on a computer screen could help save the brains and hearts of many hospital-bound people with an irregular heartbeat, a new clinical trial reveals. Rates for heart attack and stroke plunged by close to 90 percent in people helped by the new program, the study found. The computer alert warns doctors… Read More »

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Treatment for Diffuse Large B-cell Lymphoma Gets FDA Fast Track Designation

The FDA has granted a fast track designation to selinexor for the treatment of patients with previously treated diffuse large B-cell lymphoma (DLBCL) who are ineligible to receive high-dose chemotherapy with stem cell rescue or chimeric antigen receptor (CAR) T-cell therapy, according to Karyopharm Therapeutics, Inc., the manufacturer of the first-in-class SINE compound.1 The designation... Read More »

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The FDA has granted a fast track designation to selinexor for the treatment of patients with previously treated diffuse large B-cell lymphoma (DLBCL) who are ineligible to receive high-dose chemotherapy with stem cell rescue or chimeric antigen receptor (CAR) T-cell therapy, according to Karyopharm Therapeutics, Inc., the manufacturer of the first-in-class SINE compound.1 The designation… Read More »

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Three-drug combination improves life for cystic fibrosis patients

“Within 24 hours of taking the pill combination, patients were puffing less, their sinuses were clearer, they had more energy,” one researcher said. All newborns in the U.S. are tested for the genes that cause cystic fibrosis. There is no cure, but new medications may improve symptoms.BSIP / UIG via Getty Images A three-drug cocktail... Read More »

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“Within 24 hours of taking the pill combination, patients were puffing less, their sinuses were clearer, they had more energy,” one researcher said. All newborns in the U.S. are tested for the genes that cause cystic fibrosis. There is no cure, but new medications may improve symptoms.BSIP / UIG via Getty Images A three-drug cocktail… Read More »

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