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"Clinical Research"

Compounded Pain Creams Ineffective for Chronic Pain

Compounded topical pain creams work no better than placebo creams and should not be used to treat chronic pain, according to a new study published in the Annals of Internal Medicine. Researchers at the Walter Reed National Military Medical Center enrolled nearly 400 people with chronic neuropathic, joint or muscle pain in the study. Some... Read More »

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Compounded topical pain creams work no better than placebo creams and should not be used to treat chronic pain, according to a new study published in the Annals of Internal Medicine. Researchers at the Walter Reed National Military Medical Center enrolled nearly 400 people with chronic neuropathic, joint or muscle pain in the study. Some… Read More »

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“Christmas Berry” Plant Compound Could Fight Uveal Melanoma

A molecule derived from a type of primrose could prove to be a potent inhibitor of metastatic growth for a rare and aggressive cancer. Christmas berry plant (Ardisia crenata) PHILADELPHIA — Doctors diagnose about 2,000 adults with uveal melanoma, a cancer of the eye, every year. In half of cases, the disease metastasizes to the... Read More »

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A molecule derived from a type of primrose could prove to be a potent inhibitor of metastatic growth for a rare and aggressive cancer. Christmas berry plant (Ardisia crenata) PHILADELPHIA — Doctors diagnose about 2,000 adults with uveal melanoma, a cancer of the eye, every year. In half of cases, the disease metastasizes to the… Read More »

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Chemo ‘Cocktail’ Embraced as Pancreatic Cancer Breakthrough

When researchers announced that a four-drug chemotherapy regimen can add years to the lives of some patients with earlier-stage pancreatic cancer, doctors didn’t wait. Trial results were released last spring, and were immediately “practice-changing,” said Dr. Hedy Kindler, an oncologist at the University of Chicago who was not involved in the trial. Dr. James Biagi,... Read More »

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When researchers announced that a four-drug chemotherapy regimen can add years to the lives of some patients with earlier-stage pancreatic cancer, doctors didn’t wait. Trial results were released last spring, and were immediately “practice-changing,” said Dr. Hedy Kindler, an oncologist at the University of Chicago who was not involved in the trial. Dr. James Biagi,… Read More »

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Australian researchers develop 10-minute cancer test

Researchers in Australia have developed a 10-minute test that can detect the presence of cancer cells anywhere in the human body, according to a newly published study. The test was developed after researchers from the University of Queensland found that cancer forms a unique DNA structure when placed in water. The test works by identifying... Read More »

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Researchers in Australia have developed a 10-minute test that can detect the presence of cancer cells anywhere in the human body, according to a newly published study. The test was developed after researchers from the University of Queensland found that cancer forms a unique DNA structure when placed in water. The test works by identifying… Read More »

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E-Alerts Dramatically Cut Heart Attack Rate for People Hospitalized With A-Fib

A simple pop-up alert on a computer screen could help save the brains and hearts of many hospital-bound people with an irregular heartbeat, a new clinical trial reveals. Rates for heart attack and stroke plunged by close to 90 percent in people helped by the new program, the study found. The computer alert warns doctors... Read More »

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A simple pop-up alert on a computer screen could help save the brains and hearts of many hospital-bound people with an irregular heartbeat, a new clinical trial reveals. Rates for heart attack and stroke plunged by close to 90 percent in people helped by the new program, the study found. The computer alert warns doctors… Read More »

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Treatment for Diffuse Large B-cell Lymphoma Gets FDA Fast Track Designation

The FDA has granted a fast track designation to selinexor for the treatment of patients with previously treated diffuse large B-cell lymphoma (DLBCL) who are ineligible to receive high-dose chemotherapy with stem cell rescue or chimeric antigen receptor (CAR) T-cell therapy, according to Karyopharm Therapeutics, Inc., the manufacturer of the first-in-class SINE compound.1 The designation... Read More »

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The FDA has granted a fast track designation to selinexor for the treatment of patients with previously treated diffuse large B-cell lymphoma (DLBCL) who are ineligible to receive high-dose chemotherapy with stem cell rescue or chimeric antigen receptor (CAR) T-cell therapy, according to Karyopharm Therapeutics, Inc., the manufacturer of the first-in-class SINE compound.1 The designation… Read More »

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Three-drug combination improves life for cystic fibrosis patients

“Within 24 hours of taking the pill combination, patients were puffing less, their sinuses were clearer, they had more energy,” one researcher said. All newborns in the U.S. are tested for the genes that cause cystic fibrosis. There is no cure, but new medications may improve symptoms.BSIP / UIG via Getty Images A three-drug cocktail... Read More »

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“Within 24 hours of taking the pill combination, patients were puffing less, their sinuses were clearer, they had more energy,” one researcher said. All newborns in the U.S. are tested for the genes that cause cystic fibrosis. There is no cure, but new medications may improve symptoms.BSIP / UIG via Getty Images A three-drug cocktail… Read More »

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Only One-Third of Trials Supporting FDA Approval of Cancer Drugs Met the ESMO-MCBS Criteria for Substantial Clinical Benefit

When the European Society of Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) was used to evaluate trials in cancer that were the basis of US Food and Drug Administration (FDA) approvals, researchers found that only one-third of the studies demonstrated a substantial clinical benefit, which was defined as grade A or grade B for... Read More »

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When the European Society of Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) was used to evaluate trials in cancer that were the basis of US Food and Drug Administration (FDA) approvals, researchers found that only one-third of the studies demonstrated a substantial clinical benefit, which was defined as grade A or grade B for… Read More »

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Novartis CAR-T likely improves long-term survival and is cost-effective, study finds

Still, despite costs largely in line with the therapy’s benefits, the study’s author and another expert said reimbursement models have not kept up and need improvement. Novartis’ CAR-T therapy for acute lymphoblastic leukemia in pediatric patients appears to significantly increase survival while exerting costs to the healthcare system that are in line with its benefits,... Read More »

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Still, despite costs largely in line with the therapy’s benefits, the study’s author and another expert said reimbursement models have not kept up and need improvement. Novartis’ CAR-T therapy for acute lymphoblastic leukemia in pediatric patients appears to significantly increase survival while exerting costs to the healthcare system that are in line with its benefits,… Read More »

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For Women Over 30, There May Be A Better Choice Than The Pap Smear

BSIP/UIG via Getty Images For most women under 65, a visit to the gynecologist often includes an unpleasant necessity: a Pap smear to check for cervical cancer risk. The test involves letting a doctor or nurse scrape cells from the back of the cervix, which are visually inspected for signs of abnormality. There’s a simpler... Read More »

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BSIP/UIG via Getty Images For most women under 65, a visit to the gynecologist often includes an unpleasant necessity: a Pap smear to check for cervical cancer risk. The test involves letting a doctor or nurse scrape cells from the back of the cervix, which are visually inspected for signs of abnormality. There’s a simpler… Read More »

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