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Only One-Third of Trials Supporting FDA Approval of Cancer Drugs Met the ESMO-MCBS Criteria for Substantial Clinical Benefit

When the European Society of Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) was used to evaluate trials in cancer that were the basis of US Food and Drug Administration (FDA) approvals, researchers found that only one-third of the studies demonstrated a substantial clinical benefit, which was defined as grade A or grade B for... Read More »

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When the European Society of Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) was used to evaluate trials in cancer that were the basis of US Food and Drug Administration (FDA) approvals, researchers found that only one-third of the studies demonstrated a substantial clinical benefit, which was defined as grade A or grade B for… Read More »

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Novartis CAR-T likely improves long-term survival and is cost-effective, study finds

Still, despite costs largely in line with the therapy’s benefits, the study’s author and another expert said reimbursement models have not kept up and need improvement. Novartis’ CAR-T therapy for acute lymphoblastic leukemia in pediatric patients appears to significantly increase survival while exerting costs to the healthcare system that are in line with its benefits,... Read More »

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Still, despite costs largely in line with the therapy’s benefits, the study’s author and another expert said reimbursement models have not kept up and need improvement. Novartis’ CAR-T therapy for acute lymphoblastic leukemia in pediatric patients appears to significantly increase survival while exerting costs to the healthcare system that are in line with its benefits,… Read More »

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Cervical cancer: Australia ‘to be first to eliminate disease’

Cervical cancer is being successfully reduced by prevention schemes Australia will become the first country to effectively eliminate cervical cancer if vaccination and screening rates are maintained, researchers say. The disease could be eradicated as a public health issue nationally within 20 years, according to new modelling. It is predicted to be classified as a... Read More »

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Cervical cancer is being successfully reduced by prevention schemes Australia will become the first country to effectively eliminate cervical cancer if vaccination and screening rates are maintained, researchers say. The disease could be eradicated as a public health issue nationally within 20 years, according to new modelling. It is predicted to be classified as a… Read More »

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This Medical Clip May Be a Powerful Treatment for Heart Failure, Study Says

A seemingly simple but sophisticated clip may usher in a “new era” for patients suffering from a severe and difficult-to-treat complication of heart failure, according to a new study. The device, called the MitraClip, reduced hospitalizations related to heart failure by nearly half and deaths by nearly 40% among patients with a specific and serious... Read More »

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A seemingly simple but sophisticated clip may usher in a “new era” for patients suffering from a severe and difficult-to-treat complication of heart failure, according to a new study. The device, called the MitraClip, reduced hospitalizations related to heart failure by nearly half and deaths by nearly 40% among patients with a specific and serious… Read More »

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Novel Scanner Technique Can Potentially Replace Mammograms for Breast Cancer Detection

A new laser-sonic scanner technique may help women avoid the discomfort of traditional mammography procedures by offering an alternative, more efficient way to screen for breast cancer, according to a recent study. Although mammograms are effective in detecting breast cancer and reducing deaths from the disease, many women avoid having their mammograms taken as often... Read More »

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A new laser-sonic scanner technique may help women avoid the discomfort of traditional mammography procedures by offering an alternative, more efficient way to screen for breast cancer, according to a recent study. Although mammograms are effective in detecting breast cancer and reducing deaths from the disease, many women avoid having their mammograms taken as often… Read More »

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For Women Over 30, There May Be A Better Choice Than The Pap Smear

BSIP/UIG via Getty Images For most women under 65, a visit to the gynecologist often includes an unpleasant necessity: a Pap smear to check for cervical cancer risk. The test involves letting a doctor or nurse scrape cells from the back of the cervix, which are visually inspected for signs of abnormality. There’s a simpler... Read More »

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BSIP/UIG via Getty Images For most women under 65, a visit to the gynecologist often includes an unpleasant necessity: a Pap smear to check for cervical cancer risk. The test involves letting a doctor or nurse scrape cells from the back of the cervix, which are visually inspected for signs of abnormality. There’s a simpler… Read More »

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Cellectis publishes description of new ‘all-in-one’ CAR-T architecture

One of the companies developing CAR-T therapies that don’t require patients to have their own T cells harvested has developed an architecture that it said could streamline manufacturing and improve safety. French biotech firm Cellectis said Tuesday that it had published a study describing the development of CubiCAR, an “all-in-one” architecture that embeds a multi-function... Read More »

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One of the companies developing CAR-T therapies that don’t require patients to have their own T cells harvested has developed an architecture that it said could streamline manufacturing and improve safety. French biotech firm Cellectis said Tuesday that it had published a study describing the development of CubiCAR, an “all-in-one” architecture that embeds a multi-function… Read More »

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Nearly Half of Patients in Trial Respond to Checkpoint Inhibitor Treatment for Common Skin Cancer

Cutaneous squamous cell carcinoma is the second most common skin cancer, with an estimated 1 million new cases diagnosed annually. However, there are currently no systemic therapies approved for the treatment of advanced cutaneous squamous-cell carcinoma in patients who show no progress with surgery or radiation. According to recent clinical trials, an immune checkpoint inhibitor... Read More »

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Cutaneous squamous cell carcinoma is the second most common skin cancer, with an estimated 1 million new cases diagnosed annually. However, there are currently no systemic therapies approved for the treatment of advanced cutaneous squamous-cell carcinoma in patients who show no progress with surgery or radiation. According to recent clinical trials, an immune checkpoint inhibitor… Read More »

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Sunitinib (Sutent) May Spare Some Kidney Cancer Patients From Organ Removal

Many people with advanced kidney cancer might not need to have their kidneys removed during treatment, something that until now has been standard practice. Patients who only received a targeted drug for their kidney cancer survived just as well as those who had their cancerous organ removed before drug therapy, according to a new clinical... Read More »

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Many people with advanced kidney cancer might not need to have their kidneys removed during treatment, something that until now has been standard practice. Patients who only received a targeted drug for their kidney cancer survived just as well as those who had their cancerous organ removed before drug therapy, according to a new clinical… Read More »

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First 3D-printed human corneas

The first human corneas have been 3D printed by scientists at Newcastle University, UK. It means the technique could be used in the future to ensure an unlimited supply of corneas. As the outermost layer of the human eye, the cornea has an important role in focusing vision. Yet there is a significant shortage of... Read More »

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The first human corneas have been 3D printed by scientists at Newcastle University, UK. It means the technique could be used in the future to ensure an unlimited supply of corneas. As the outermost layer of the human eye, the cornea has an important role in focusing vision. Yet there is a significant shortage of… Read More »

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